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KMID : 0613820170270070834
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Journal of Life Science
2017 Volume.27 No. 7 p.834 ~ p.839
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Growth Inhibitory Effect of Extracts of Propolis on Epithelial Ovarian Cancer Cells
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Yang Ga-Ram
Yoon Kyung-Mi
Oh Hyun-Ho
Kim Min-Sung
Hwang Tae-Ho
An Won-Gun
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Abstract
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Propolis is a natural product collected from plants by honey bees product used extensively in traditional medicine for its antioxidant, anti-inflammatory, immunomodulatory and anti-cancer effects. Propolis exhibits a broad spectrum of biological activities because it is a complex mixture of natural substances. Ovarian cancer is the second most common newly diagnosed cancer from all cancers among women in Korea and the leading cause of death from gynecological malignancies. While most ovarian cancer patients initially respond to surgical debulking and chemotherapy, patients later succumb to the disease. Thus, there is an urgent need to test novel therapeutic agents to counteract the high mortality rate associated with ovarian cancer. In this study, we investigated the anti-cancer properties and the active mechanism of Australian propolis in human epithelial ovarian cancer A2780 cells. Our data revealed that propolis showed a cytotoxic activity in a dose-dependent manner. Flow cytometric analysis for cell cycle arrest and apoptosis using propidium iodide staning and annexin V-FITC indicated that propolis could induce cycle arrest in the G0/G1 phase and apoptosis in a dose-dependent manner on human epithelial ovarian cancer cells. These results suggest that the Australian propolis is potential alternative agent on ovarian cancer prevention and treatment.
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KEYWORD
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A2780, anti-cancer effects, apoptosis, cell cycle arrest, propolis
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